GCLM

Across TCGA patient cohorts, GCLM protein abundance is significantly associated with the RNA expression of many other genes, with 13,539 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GCLM-associated genes across cancer lineages are NMRAL2P, TXNRD1, and AKR1C7P. Each is linked with GCLM in more than 7 cancer types. Because this analysis shows association rather than direction, both GCLM-to-partner and partner-to-GCLM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCLM versus NMRAL2P in LSCC, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLM→partner) and Y-score (partner→GCLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NMRAL2P →	+3.591	+1.087	<.001	<.001	3	8
LSCC	TXNRD1 →	+1.539	+0.995	<.001	<.001	3	7
LSCC	AKR1C7P →	+2.267	+1.055	<.001	<.001	3	6
LSCC	G6PD →	+1.448	+1.055	<.001	<.001	3	6
LSCC	CYP4F3 →	+3.387	+1.027	<.001	<.001	3	5
LSCC	AKR1B10 →	+4.223	+1.136	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,539 associations by consensus.

GCLM vs NMRAL2P — LSCC

Explore this scatter interactively →