GCLM

Across TCGA patient cohorts, GCLM mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCLM-associated genes across cancer lineages are p62 Lck ligand, SETD2, and VHL. Each is linked with GCLM in more than 1 cancer types. Because this analysis shows association rather than direction, both GCLM-to-partner and partner-to-GCLM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GCLM-low versus GCLM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLM→partner) and Y-score (partner→GCLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.449	+2.817	.017	.036	3	1
UCEC	SETD2 →	-0.270	-3.000	.032	.037	3	1
UCEC	VHL →	-1.192	-3.000	.002	.036	3	1
UCEC	C-Raf →	+0.239	+3.000	.003	.037	3	1
UCEC	MEK1 →	+0.482	+3.000	.022	.037	2	1
UCEC	Tuberin →	+0.410	+3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p62 Lck ligand by GCLM expression — UCEC

Explore this box plot interactively →