GCLC

Across TCGA patient cohorts, GCLC mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCLC-associated genes across cancer lineages are eEF2, ATM, and Caspase-8. Each is linked with GCLC in more than 1 cancer types. Because this analysis shows association rather than direction, both GCLC-to-partner and partner-to-GCLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GCLC-low versus GCLC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLC→partner) and Y-score (partner→GCLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.257	+1.807	.035	.025	3	2
UCEC	ATM →	-0.627	-2.137	<.001	.001	3	2
UCEC	Caspase-8 →	-0.220	-3.060	.010	<.001	3	2
UCEC	EGFR_pY1068 →	-0.281	-2.523	.001	<.001	3	1
UCEC	ERK2 →	+0.181	+1.765	.005	.013	3	1
UCEC	FoxM1 →	+0.232	+2.137	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by GCLC expression — UCEC

Explore this box plot interactively →