GCLC

Across TCGA cell cohorts, GCLC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,078 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCLC-associated GO terms across cancer lineages are Response to thyroxine, Response to L-phenylalanine derivative, and Response to thyroid hormone. Each is linked with GCLC in more than 17 cancer types. Because this analysis shows association rather than direction, both GCLC-to-partner and partner-to-GCLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to thyroxine grouped by GCLC-low versus GCLC-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLC→partner) and Y-score (partner→GCLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to thyroxine →	+0.221	+1.479	<.001	<.001	3	18
BLOOD_Myeloma	Response to L-phenylalanine derivative →	+0.173	+1.103	<.001	<.001	3	17
BREAST	Response to thyroid hormone →	+0.144	+1.134	.001	.001	3	14
LUNG_SCLC	Glutathione biosynthetic process →	+0.256	+1.353	<.001	<.001	3	14
LUNG_SCLC	Nonribosomal peptide biosynthetic process →	+0.228	+1.553	<.001	<.001	3	13
LIVER	Glutamate metabolic process →	+0.203	+1.507	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,078 associations by consensus.

Response to thyroxine by GCLC expression — LUNG_SCLC

Explore this box plot interactively →