GCKR

Across TCGA patient cohorts, GCKR mutation is significantly associated with the RNA expression of many other genes, with 3,429 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCKR-associated genes across cancer lineages are CCT5, CDCA5, and MRPS18B. Each is linked with GCKR in more than 2 cancer types. Because this analysis shows association rather than direction, both GCKR-to-partner and partner-to-GCKR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT5 grouped by GCKR-low versus GCKR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCKR→partner) and Y-score (partner→GCKR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT5 →	+0.576	+3.861	<.001	<.001	3	3
UCEC	CDCA5 →	+0.909	+2.273	<.001	<.001	3	3
LUSC	MRPS18B →	+0.645	+3.229	<.001	.009	3	2
LUSC	HSPA8P13 →	+0.493	+2.622	.002	.005	3	2
BLCA	LINC02327 →	+0.923	+2.952	<.001	.007	3	2
LUSC	MIR4443 →	+0.188	+3.906	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,429 associations by consensus.

CCT5 by GCKR expression — UCEC

Explore this box plot interactively →