GCKR

Across TCGA patient cohorts, GCKR mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCKR-associated genes across cancer lineages are C-Raf, JNK2, and 4E-BP1_pS65. Each is linked with GCKR in more than 2 cancer types. Because this analysis shows association rather than direction, both GCKR-to-partner and partner-to-GCKR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by GCKR-low versus GCKR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCKR→partner) and Y-score (partner→GCKR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.198	+2.906	<.001	.001	3	3
UCEC	JNK2 →	+0.271	+3.710	<.001	<.001	3	2
SKCM	4E-BP1_pS65 →	+0.195	+2.321	.048	.035	3	2
UCEC	Notch1 →	+0.193	+2.321	<.001	.001	3	2
UCEC	AR →	-0.452	-3.584	<.001	.002	3	2
UCEC	TFRC →	+0.559	+3.584	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

C-Raf by GCKR expression — UCEC

Explore this box plot interactively →