GCKR

Across TCGA cell cohorts, GCKR mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCKR-associated genes across cancer lineages are NXPH2, DTHD1, and OPRPN. Each is linked with GCKR in more than 1 cancer types. Because this analysis shows association rather than direction, both GCKR-to-partner and partner-to-GCKR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXPH2 grouped by GCKR-low versus GCKR-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCKR→partner) and Y-score (partner→GCKR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NXPH2 →	+0.022	+4.017	<.001	.007	3	1
OESOPHAGUS	DTHD1 →	+0.022	+4.857	<.001	<.001	3	1
LUNG_SCLC	OPRPN →	+0.139	+5.029	<.001	.006	3	1
LUNG_SCLC	OR1L6 →	+0.049	+5.029	<.001	.006	3	1
LUNG_SCLC	OR9I1 →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	FIGLA →	+0.053	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

NXPH2 by GCKR expression — OESOPHAGUS

Explore this box plot interactively →