GCKR

Across TCGA cell cohorts, GCKR mutation is significantly associated with the mutation status of many other genes, with 2,479 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCKR-associated genes across cancer lineages are CHRM3, ZBTB21, and KIF4B. Each is linked with GCKR in more than 3 cancer types. Because this analysis shows association rather than direction, both GCKR-to-partner and partner-to-GCKR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRM3 grouped by GCKR-low versus GCKR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCKR→partner) and Y-score (partner→GCKR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CHRM3 →	+5.502	+5.502	.003	.003	1	4
SOFT_TISSUE	ZBTB21 →	+5.502	+5.502	.003	.003	1	4
SOFT_TISSUE	KIF4B →	+4.502	+5.066	.007	.007	1	4
LARGE_INTESTINE	NOBOX →	+3.007	+3.584	.008	.008	1	4
LARGE_INTESTINE	CDH9 →	+2.043	+3.693	.009	.009	1	4
LARGE_INTESTINE	HEG1 →	+2.043	+3.693	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,479 associations by consensus.

CHRM3 by GCKR expression — SOFT_TISSUE

Explore this box plot interactively →