GCK

Across TCGA patient cohorts, GCK protein abundance is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GCK-associated genes across cancer lineages are HHLA2, MAPKAPK3, and LDLR. Each is linked with GCK in more than 1 cancer types. Because this analysis shows association rather than direction, both GCK-to-partner and partner-to-GCK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCK versus HHLA2 in GBM, with a Pearson correlation of -0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCK→partner) and Y-score (partner→GCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HHLA2 →	-0.214	-0.405	.007	.005	3	1
GBM	MAPKAPK3 →	-0.748	-0.412	<.001	.003	3	1
GBM	LDLR →	+1.653	+0.549	.005	.007	3	1
GBM	TSPAN33 →	-1.085	-0.412	.005	.003	3	1
GBM	CCDC42 →	-0.224	-0.412	<.001	.003	3	1
GBM	POLR2J3 →	+1.055	+0.486	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

GCK vs HHLA2 — GBM

Explore this scatter interactively →