GCK

Across TCGA cell cohorts, GCK RNA expression is significantly associated with the go_rna of many other GO terms, with 1,893 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GCK-associated GO terms across cancer lineages are Purine ribonucleotide metabolic process, Ribonucleotide metabolic process, and Protein targeting to lysosome involved in chaperone-mediated autophagy. Each is linked with GCK in more than 7 cancer types. Because this analysis shows association rather than direction, both GCK-to-partner and partner-to-GCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine ribonucleotide metabolic process grouped by GCK-low versus GCK-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCK→partner) and Y-score (partner→GCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Purine ribonucleotide metabolic process →	+0.040	+0.403	.003	.001	3	8
OVARY	Ribonucleotide metabolic process →	+0.043	+0.552	.008	.002	3	8
SOFT_TISSUE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.151	+0.326	<.001	.004	3	7
SOFT_TISSUE	Maintenance of protein location in cell →	+0.116	+0.395	<.001	<.001	3	7
SOFT_TISSUE	Maintenance of protein location →	+0.118	+0.393	<.001	<.001	3	7
BLOOD_Lymphoma	Response to misfolded protein →	+0.055	+0.293	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,893 associations by consensus.

Purine ribonucleotide metabolic process by GCK expression — SKIN

Explore this box plot interactively →