GCK

Across TCGA cell cohorts, GCK mutation is significantly associated with the mutation status of many other genes, with 5,250 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCK-associated genes across cancer lineages are BRAT1, RIMS1, and PDCD11. Each is linked with GCK in more than 3 cancer types. Because this analysis shows association rather than direction, both GCK-to-partner and partner-to-GCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRAT1 grouped by GCK-low versus GCK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCK→partner) and Y-score (partner→GCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRAT1 →	+3.560	+4.247	.002	.002	1	4
BLOOD_Leukemia	RIMS1 →	+3.823	+4.430	.001	.001	1	4
BLOOD_Lymphoma	PDCD11 →	+5.014	+5.584	.003	.003	1	4
LUNG_NSCLC_LUAD	ZC3H18 →	+4.772	+5.339	.004	.004	1	4
BLOOD_Leukemia	RAPGEF6 →	+3.145	+3.932	.004	.004	1	4
BLOOD_Leukemia	TRANK1 →	+2.860	+4.640	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,250 associations by consensus.

BRAT1 by GCK expression — BLOOD_Leukemia

Explore this box plot interactively →