GCHFR

Across TCGA pan-cancer cohorts, GCHFR mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GCHFR data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GCHFR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GCHFR expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, COAD, and CCRCC are the cancer types where GCHFR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.469	.003	30	view →
COAD	DFS	Median	II,III,IV	0.908	1.000	.009	24	view →
CCRCC	DFS	Median	All	0.903	0.535	.008	22	view →
LUAD	DFS	Median	All	0.478	0.720	.013	5	view →
PDAC	OS	Quartile	All	0.957	0.721	.011	4	view →
GBM	DFS	Median	All	0.428	0.300	.036	4	view →
HNSC	DFS	Quartile	II,III,IV	0.921	1.000	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GCHFR–UCEC (DFS)

Open the UCEC breakdown →