GCH1

Across TCGA pan-cancer cohorts, GCH1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GCH1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GCH1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GCH1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where GCH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.959	0.680	.002	44	view →
LUAD	OS	Median	II,III,IV	0.385	0.792	.001	13	view →
LSCC	OS	Median	II,III,IV	0.596	0.886	.012	6	view →
HNSC	OS	Quartile	IV	0.900	0.597	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GCH1–CCRCC (DFS)

Open the CCRCC breakdown →