GCH1

Across TCGA patient cohorts, GCH1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCH1-associated genes across cancer lineages are MEK1, 4E-BP1, and 14-3-3_beta. Each is linked with GCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCH1-to-partner and partner-to-GCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GCH1-low versus GCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCH1→partner) and Y-score (partner→GCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.542	+3.584	<.001	.002	3	2
UCEC	4E-BP1 →	+0.320	+3.199	.008	.009	3	2
UCEC	14-3-3_beta →	-0.090	-2.973	.046	.035	3	1
UCEC	eEF2 →	+0.478	+2.999	.002	.035	3	1
UCEC	EGFR_pY1068 →	-0.244	-3.000	.031	.036	3	1
UCEC	A-Raf_pS299 →	-0.126	-2.321	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MEK1 by GCH1 expression — UCEC

Explore this box plot interactively →