GCH1

Across TCGA cell cohorts, GCH1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCH1-associated genes across cancer lineages are DEFA3, GUCA1C, and CYP39A1. Each is linked with GCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCH1-to-partner and partner-to-GCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA3 grouped by GCH1-low versus GCH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCH1→partner) and Y-score (partner→GCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA3 →	+0.102	+5.415	<.001	.004	3	1
BLOOD_Leukemia	GUCA1C →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CYP39A1 →	+0.114	+3.769	.009	.008	3	1
BLOOD_Leukemia	OR13J1 →	+0.162	+3.774	<.001	.008	3	1
BLOOD_Leukemia	AQP12A →	+0.091	+4.269	<.001	.002	3	1
BLOOD_Leukemia	RNF133 →	+0.057	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

DEFA3 by GCH1 expression — LARGE_INTESTINE

Explore this box plot interactively →