GCH1

Across TCGA cell cohorts, GCH1 mutation is significantly associated with the mutation status of many other genes, with 846 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCH1-associated genes across cancer lineages are SEC14L3, C14orf93, and FERMT1. Each is linked with GCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCH1-to-partner and partner-to-GCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC14L3 grouped by GCH1-low versus GCH1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCH1→partner) and Y-score (partner→GCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SEC14L3 →	+4.560	+4.870	<.001	<.001	1	2
BLOOD_Leukemia	C14orf93 →	+3.823	+4.430	.001	.001	1	2
BLOOD_Leukemia	FERMT1 →	+5.560	+4.736	.003	.003	1	2
BLOOD_Leukemia	MAGED2 →	+4.145	+4.635	.001	.001	1	2
BLOOD_Leukemia	VAC14 →	+4.145	+4.635	.001	.001	1	2
BLOOD_Leukemia	RIPK2 →	+5.560	+4.736	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 846 associations by consensus.

SEC14L3 by GCH1 expression — BLOOD_Leukemia

Explore this box plot interactively →