Across TCGA patient cohorts, GCGR mutation is significantly associated with the RNA expression of many other genes, with 1,427 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCGR-associated genes across cancer lineages are RNA5SP76, BTBD10, and LIN7C. Each is linked with GCGR in more than 1 cancer types. Because this analysis shows association rather than direction, both GCGR-to-partner and partner-to-GCGR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCGR→partner) and Y-score (partner→GCGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP76 →	+0.585	+7.731	<.001	.009	3	1
UCEC	BTBD10 →	+0.481	+2.922	.001	<.001	3	1
UCEC	LIN7C →	+0.538	+2.423	.002	.001	3	1
UCEC	IMMP1L →	+0.355	+2.673	.008	<.001	3	1
UCEC	EIF3M →	+0.431	+2.695	.005	<.001	3	1
UCEC	COX15 →	+0.468	+2.815	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,427 associations by consensus.

Exploration

GCGR survival (RNA) · tumor vs normal (RNA) · all GCGR data types