Across TCGA patient cohorts, GCGR mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCGR-associated genes across cancer lineages are eIF4E, ERK2, and ACVRL1. Each is linked with GCGR in more than 1 cancer types. Because this analysis shows association rather than direction, both GCGR-to-partner and partner-to-GCGR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCGR→partner) and Y-score (partner→GCGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+3.013	.039	.018	3	1
UCEC	ERK2 →	+0.174	+2.000	.028	.030	3	1
UCEC	ACVRL1 →	-0.123	-3.156	.028	.018	3	1
UCEC	Ku80 →	+0.201	+2.820	.039	.035	3	1
UCEC	MEK1 →	+0.472	+3.000	.001	.001	3	1
UCEC	Notch1 →	+0.143	+1.884	.014	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

GCGR survival (RNA) · tumor vs normal (RNA) · all GCGR data types