GCFC2

Across TCGA patient cohorts, GCFC2 mutation is significantly associated with the RNA expression of many other genes, with 5,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCFC2-associated genes across cancer lineages are PGAM1P9, MIR575, and RAC1P7. Each is linked with GCFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCFC2-to-partner and partner-to-GCFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM1P9 grouped by GCFC2-low versus GCFC2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCFC2→partner) and Y-score (partner→GCFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	PGAM1P9 →	+0.084	+6.149	<.001	.002	3	2
KIRP	MIR575 →	+0.365	+5.770	<.001	.003	3	2
KIRP	RAC1P7 →	+0.139	+5.628	<.001	.004	3	2
ESCA	MTND1P31 →	+0.035	+5.954	<.001	.002	3	2
CESC	RPSAP32 →	+0.115	+5.306	<.001	.006	3	2
SKCM	LINC02304 →	+0.042	+4.039	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,153 associations by consensus.

PGAM1P9 by GCFC2 expression — LIHC

Explore this box plot interactively →