GCFC2

Across TCGA cell cohorts, GCFC2 mutation is significantly associated with the RNA expression of many other genes, with 185 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCFC2-associated genes across cancer lineages are CRYBB1, SCGB1C2, and ETDC. Each is linked with GCFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCFC2-to-partner and partner-to-GCFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by GCFC2-low versus GCFC2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCFC2→partner) and Y-score (partner→GCFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CRYBB1 →	+0.026	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	SCGB1C2 →	+0.116	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	ETDC →	+0.556	+5.209	<.001	.005	3	1
LARGE_INTESTINE	HMGXB4 →	+0.543	+3.067	.004	.009	3	1
LARGE_INTESTINE	DESI1 →	+0.423	+2.451	.009	.009	3	1
LARGE_INTESTINE	PSMD14 →	+0.308	+3.588	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 185 associations by consensus.

CRYBB1 by GCFC2 expression — OESOPHAGUS

Explore this box plot interactively →