Across TCGA pan-cancer cohorts, GCC2-AS1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated GCC2-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GCC2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GCC2-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LAML show a favorable association.

KIRC, KIRP, and LUAD are the cancer types where GCC2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.422	0.610	.001	91	view →
KIRP	DFS	Tertile	All	0.583	0.813	.003	54	view →
LUAD	DFS	Median	All	0.251	0.474	.002	38	view →
HNSC	OS	Tertile	All	0.215	0.545	<.001	27	view →
BLCA	DFS	Median	III,IV	0.574	0.353	<.001	21	view →
ACC	DFS	Quartile	All	0.279	0.583	.014	18	view →
KICH	DFS	Median	III,IV	0.327	0.890	.005	18	view →
LAML	DFS	Tertile	All	0.548	0.364	.014	18	view →
LGG	DFS	Tertile	All	0.252	0.485	<.001	17	view →
GBM	OS	Median	All	0.213	0.315	.005	15	view →
LIHC	DFS	Quartile	All	0.374	0.670	.002	15	view →
COAD	DFS	Median	IV	0.215	0.439	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

Exploration

Same gene, other analysis: GCC2-AS1 tumor-vs-normal RNA expression · all GCC2-AS1 data types