GCC1

Across TCGA pan-cancer cohorts, GCC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GCC1 data layer compared with 31 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GCC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GCC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where GCC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.926	0.487	.004	24	view →
PDAC	DFS	Median	All	0.564	0.325	.003	21	view →
LUAD	OS	Median	III,IV	0.800	0.348	.003	21	view →
HNSC	DFS	Quartile	II,III,IV	0.777	0.523	.039	3	view →
GBM	DFS	Tertile	All	0.582	0.833	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GCC1–UCEC (DFS)

Open the UCEC breakdown →