GCAT

Across TCGA patient cohorts, GCAT mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCAT-associated genes across cancer lineages are ASNS, FoxM1, and JNK2. Each is linked with GCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both GCAT-to-partner and partner-to-GCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GCAT-low versus GCAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCAT→partner) and Y-score (partner→GCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.566	+3.169	<.001	.019	3	2
UCEC	FoxM1 →	+0.358	+3.179	.002	.010	3	1
UCEC	JNK2 →	+0.276	+2.834	.002	.034	3	1
UCEC	Tuberin_pT1462 →	+0.264	+1.884	.014	.030	3	1
UCEC	VHL →	-1.117	-3.459	<.001	.005	3	1
UCEC	C-Raf →	+0.169	+3.000	.011	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ASNS by GCAT expression — UCEC

Explore this box plot interactively →