GCAT

Across TCGA cell cohorts, GCAT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,018 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GCAT-associated GO terms across cancer lineages are L-threonine metabolic process, L-threonine catabolic process, and Amino acid metabolic process. Each is linked with GCAT in more than 16 cancer types. Because this analysis shows association rather than direction, both GCAT-to-partner and partner-to-GCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-threonine metabolic process grouped by GCAT-low versus GCAT-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCAT→partner) and Y-score (partner→GCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	L-threonine metabolic process →	+0.311	+1.161	<.001	<.001	3	17
LUNG_SCLC	L-threonine catabolic process →	+0.311	+1.161	<.001	<.001	3	17
LARGE_INTESTINE	Amino acid metabolic process →	+0.053	+1.120	.003	.002	3	10
LARGE_INTESTINE	Proteinogenic amino acid metabolic process →	+0.091	+1.439	<.001	<.001	3	9
LARGE_INTESTINE	L-amino acid metabolic process →	+0.088	+1.485	<.001	<.001	3	9
STOMACH	L-amino acid catabolic process →	+0.072	+0.945	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,018 associations by consensus.

L-threonine metabolic process by GCAT expression — LUNG_SCLC

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