GCAT

Across TCGA cell cohorts, GCAT mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCAT-associated genes across cancer lineages are OTOP1, ODF3, and LACRT. Each is linked with GCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both GCAT-to-partner and partner-to-GCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOP1 grouped by GCAT-low versus GCAT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCAT→partner) and Y-score (partner→GCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OTOP1 →	+0.475	+3.762	.003	.003	3	1
LARGE_INTESTINE	ODF3 →	+0.037	+3.836	<.001	.003	3	1
LUNG_NSCLC_LUAD	LACRT →	+0.193	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRTAP10-11 →	+0.018	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OTOP1 by GCAT expression — LARGE_INTESTINE

Explore this box plot interactively →