GCA

Across TCGA pan-cancer cohorts, GCA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GCA data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GCA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GCA expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where GCA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.617	0.857	.002	35	view →
LUAD	OS	Median	III,IV	0.211	0.677	.003	18	view →
GBM	DFS	Quartile	All	0.675	0.907	.012	6	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GCA–CCRCC (DFS)

Open the CCRCC breakdown →