GCA

Across TCGA patient cohorts, GCA RNA expression is significantly associated with the protein abundance of many other proteins, with 10,892 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GCA-associated proteins across cancer lineages are C1QBP, MYO1F_S1023, and FES_T421. Each is linked with GCA in more than 4 cancer types. Because this analysis shows association rather than direction, both GCA-to-partner and partner-to-GCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCA versus C1QBP in HNSC, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GCA→partner) and Y-score (partner→GCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	C1QBP →	-0.437	-0.843	<.001	<.001	3	5
LSCC	MYO1F_S1023 →	+0.747	+0.515	.003	.001	3	4
LSCC	FES_T421 →	+0.782	+0.568	<.001	<.001	3	4
BRCA	MRPL13 →	-0.283	-0.476	.007	.005	3	4
LSCC	MRPL16 →	-0.401	-0.761	<.001	<.001	3	4
LSCC	MRPL47 →	-0.327	-0.480	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,892 associations by consensus.

GCA vs C1QBP — HNSC

Explore this scatter interactively →