GCA

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GCA protein abundance is significantly associated with the RNA expression of many other genes, with 15,643 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GCA-associated genes across cancer lineages are AQP9, FCGR3B, and CXCL1. Each is linked with GCA in more than 8 cancer types. Because this analysis shows association rather than direction, both GCA-to-partner and partner-to-GCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCA versus AQP9 in CCRCC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCA→partner) and Y-score (partner→GCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCAQP9 →+1.618+0.356<.001<.00139
LSCCFCGR3B →+1.738+0.643<.001<.00139
LSCCCXCL1 →+2.001+0.564<.001<.00139
GBMCXCL8 →+2.399+0.599<.001<.00139
GBMFPR2 →+1.301+0.607<.001<.00139
COADADGRG3 →+1.211+0.787<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 15,643 associations by consensus.

GCA vs AQP9 — CCRCC

Per-sample scatter of GCA vs AQP9 in CCRCC (Pearson r = 0.40).

Explore this scatter interactively →

Exploration