GCA

Across TCGA patient cohorts, GCA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCA-associated genes across cancer lineages are 14-3-3_beta, ERK2, and HER2_pY1248. Each is linked with GCA in more than 1 cancer types. Because this analysis shows association rather than direction, both GCA-to-partner and partner-to-GCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GCA-low versus GCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCA→partner) and Y-score (partner→GCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-3.143	.014	.018	3	1
UCEC	ERK2 →	+0.223	+2.999	.006	.035	3	1
UCEC	HER2_pY1248 →	-0.226	-4.000	.046	<.001	3	1
UCEC	INPP4B →	-0.323	-2.321	.018	.033	3	1
UCEC	IRS1 →	-0.200	-1.700	.023	.044	3	1
UCEC	Ku80 →	+0.231	+2.235	.021	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by GCA expression — UCEC

Explore this box plot interactively →