GCA

Across TCGA cell cohorts, GCA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,381 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCA-associated GO terms across cancer lineages are Membrane fusion, Geranylgeranyl diphosphate metabolic process, and Geranylgeranyl diphosphate biosynthetic process. Each is linked with GCA in more than 9 cancer types. Because this analysis shows association rather than direction, both GCA-to-partner and partner-to-GCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane fusion grouped by GCA-low versus GCA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCA→partner) and Y-score (partner→GCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Membrane fusion →	+0.079	+2.197	<.001	<.001	3	10
LARGE_INTESTINE	Geranylgeranyl diphosphate metabolic process →	+0.098	+0.826	<.001	.001	3	9
LUNG_SCLC	Geranylgeranyl diphosphate biosynthetic process →	+0.139	+1.688	<.001	.001	2	10
LUNG_SCLC	Alcohol biosynthetic process →	+0.085	+1.570	<.001	<.001	3	9
LUNG_SCLC	Protein folding in endoplasmic reticulum →	+0.111	+2.140	<.001	<.001	3	8
BONE	Collagen fibril organization →	-0.366	-1.670	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,381 associations by consensus.

Membrane fusion by GCA expression — BREAST

Explore this box plot interactively →