GBX2

Across TCGA patient cohorts, GBX2 mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GBX2-associated genes across cancer lineages are MRPL32P1, MIR1237, and CYCSP25. Each is linked with GBX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBX2-to-partner and partner-to-GBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL32P1 grouped by GBX2-low versus GBX2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBX2→partner) and Y-score (partner→GBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MRPL32P1 →	+0.176	+5.147	<.001	.003	3	4
LUSC	MIR1237 →	+0.525	+7.102	<.001	<.001	3	3
CESC	CYCSP25 →	+0.138	+3.705	<.001	.008	3	2
BLCA	OR5H7P →	+0.037	+5.618	<.001	.002	3	2
BLCA	FGFR3P6 →	+0.086	+4.497	<.001	.009	3	2
BLCA	RN7SL174P →	+0.546	+4.680	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

MRPL32P1 by GBX2 expression — BLCA

Explore this box plot interactively →