GBX2

Across TCGA patient cohorts, GBX2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBX2-associated genes across cancer lineages are FoxM1, INPP4B, and p27_pT157. Each is linked with GBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBX2-to-partner and partner-to-GBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GBX2-low versus GBX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBX2→partner) and Y-score (partner→GBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.335	+3.000	.025	.037	3	1
UCEC	INPP4B →	-0.400	-2.986	.032	.037	3	1
UCEC	p27_pT157 →	-0.070	-2.960	.036	.036	3	1
UCEC	PCNA →	+0.250	+3.000	.045	.037	3	1
UCEC	Rab11 →	-0.185	-3.000	.027	.037	3	1
UCEC	JNK2 →	+0.250	+3.000	.029	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FoxM1 by GBX2 expression — UCEC

Explore this box plot interactively →