GBX2

Across TCGA cell cohorts, GBX2 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GBX2-associated genes across cancer lineages are EPZ004777, LMB_AB1, and VNLG/124. Each is linked with GBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBX2-to-partner and partner-to-GBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPZ004777 grouped by GBX2-low versus GBX2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBX2→partner) and Y-score (partner→GBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPZ004777 →	-0.252	-3.063	.015	.015	3	1
BLOOD_Leukemia	LMB_AB1 →	+0.320	+3.000	.002	.025	3	1
BLOOD_Leukemia	VNLG/124 →	-0.525	-3.000	.026	.021	3	1
BLOOD_Leukemia	Refametinib →	-0.684	-2.999	.033	.023	2	1
BLOOD_Leukemia	Tamoxifen →	+0.274	+3.169	.019	.014	2	1
BLOOD_Leukemia	AZ960 →	-0.418	-2.999	.029	.028	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EPZ004777 by GBX2 expression — BLOOD_Leukemia

Explore this box plot interactively →