Across TCGA patient cohorts, GBP7 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP7-associated genes across cancer lineages are MEK1, PDCD4, and ATM. Each is linked with GBP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP7-to-partner and partner-to-GBP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP7→partner) and Y-score (partner→GBP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.392	+2.502	.002	.001	3	2
UCEC	PDCD4 →	-0.389	-1.584	.021	.019	3	2
UCEC	ATM →	-0.514	-2.308	.001	.033	3	2
UCEC	Cyclin-B1 →	+0.693	+2.321	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.082	-1.847	.023	.049	3	1
UCEC	eEF2 →	+0.392	+2.700	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

GBP7 survival (RNA) · tumor vs normal (RNA) · all GBP7 data types