Across TCGA patient cohorts, GBP6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP6-associated genes across cancer lineages are CD20, MEK1, and Myosin-IIa. Each is linked with GBP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GBP6-to-partner and partner-to-GBP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP6→partner) and Y-score (partner→GBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD20 →	+0.104	+2.087	.038	.005	3	3
UCEC	MEK1 →	+0.320	+2.459	.022	.019	3	2
UCEC	Myosin-IIa →	+0.202	+2.422	.006	.002	3	2
UCEC	p70-S6K_pT389 →	-0.172	-3.169	.018	.018	3	2
UCEC	Rab25 →	-0.335	-1.678	.008	.023	3	2
UCEC	ATM →	-0.493	-2.087	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

GBP6 survival (RNA) · tumor vs normal (RNA) · all GBP6 data types