Across TCGA cell cohorts, GBP6 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GBP6-associated genes across cancer lineages are C8orf74, GZMK, and TAS2R8. Each is linked with GBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP6-to-partner and partner-to-GBP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP6→partner) and Y-score (partner→GBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C8orf74 →	+0.029	+5.369	<.001	.004	3	1
BLOOD_Leukemia	GZMK →	+0.587	+4.622	<.001	<.001	3	1
BLOOD_Leukemia	TAS2R8 →	+0.028	+2.926	.001	.009	3	1
BLOOD_Leukemia	SH3GL3 →	+1.401	+3.518	.001	.008	3	1
BLOOD_Leukemia	CALHM4 →	+0.025	+4.099	<.001	<.001	3	1
BLOOD_Leukemia	SLC35G3 →	+0.046	+3.704	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

GBP6 survival (RNA) · tumor vs normal (RNA) · all GBP6 data types