GBP5

Across TCGA patient cohorts, GBP5 mutation is significantly associated with the RNA expression of many other genes, with 1,486 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP5-associated genes across cancer lineages are RNU6-1085P, MIR526A1, and SNORD114-13. Each is linked with GBP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBP5-to-partner and partner-to-GBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1085P grouped by GBP5-low versus GBP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP5→partner) and Y-score (partner→GBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1085P →	+0.214	+2.158	<.001	.001	3	4
HNSC	MIR526A1 →	+0.282	+4.090	.001	.002	3	2
BLCA	SNORD114-13 →	+0.243	+4.147	.001	.009	3	2
CESC	VTRNA2-2P →	+0.397	+4.601	<.001	.004	3	2
UCEC	NDUFAF2 →	+0.415	+1.736	.009	.007	3	2
UCEC	FTH1 →	+0.713	+2.329	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,486 associations by consensus.

RNU6-1085P by GBP5 expression — UCEC

Explore this box plot interactively →