GBP5

Across TCGA patient cohorts, GBP5 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP5-associated genes across cancer lineages are A-Raf_pS299, FASN, and Heregulin. Each is linked with GBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP5-to-partner and partner-to-GBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by GBP5-low versus GBP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP5→partner) and Y-score (partner→GBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.097	-1.502	.027	.030	3	2
UCEC	FASN →	+0.373	+2.000	.010	.030	3	2
UCEC	Heregulin →	-0.131	-2.446	.003	.018	3	2
UCEC	p62 Lck ligand →	+0.326	+1.502	.006	.030	3	2
UCEC	PDK1_pS241 →	+0.127	+1.515	.043	.018	3	2
UCEC	Cyclin-B1 →	+0.515	+1.502	.012	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

A-Raf_pS299 by GBP5 expression — UCEC

Explore this box plot interactively →