GBP5

Across TCGA cell cohorts, GBP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,407 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible GBP5-associated GO terms across cancer lineages are Negative regulation of cytokine production, Regulation of extrinsic apoptotic signaling pathway, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with GBP5 in more than 10 cancer types. Because this analysis shows association rather than direction, both GBP5-to-partner and partner-to-GBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytokine production grouped by GBP5-low versus GBP5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP5→partner) and Y-score (partner→GBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of cytokine production →	+0.090	+0.453	<.001	<.001	3	10
STOMACH	Regulation of extrinsic apoptotic signaling pathway →	+0.084	+0.515	<.001	.009	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of canonical NF-kappaB signal transduction →	+0.074	+1.464	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.083	+1.378	<.001	<.001	3	10
BREAST	Negative regulation of molecular function →	+0.067	+0.468	<.001	<.001	3	10
BREAST	Cytoplasmic pattern recognition receptor signaling pathway →	+0.058	+0.409	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,407 associations by consensus.

Negative regulation of cytokine production by GBP5 expression — BREAST

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