GBP5

Across TCGA cell cohorts, GBP5 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBP5-associated genes across cancer lineages are JNK Inhibitor VIII, 5-Fluorouracil, and Bromosporine. Each is linked with GBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP5-to-partner and partner-to-GBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK Inhibitor VIII grouped by GBP5-low versus GBP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP5→partner) and Y-score (partner→GBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JNK Inhibitor VIII →	+0.259	+2.807	.048	.046	3	1
LARGE_INTESTINE	5-Fluorouracil →	+0.540	+3.184	.040	.007	3	1
LARGE_INTESTINE	Bromosporine →	+0.361	+3.064	.019	.009	3	1
LARGE_INTESTINE	AGI-6780 →	+0.407	+3.061	.019	.010	3	1
LARGE_INTESTINE	GSK2110183B →	+0.687	+3.064	.011	.009	3	1
LARGE_INTESTINE	Dacarbazine →	+0.286	+2.710	.023	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK Inhibitor VIII by GBP5 expression — LARGE_INTESTINE

Explore this box plot interactively →