GBP4

Across TCGA pan-cancer cohorts, GBP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GBP4 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GBP4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GBP4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where GBP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.437	0.917	.002	12	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.077	.024	7	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	7	view →
UCEC	DFS	Median	II,III,IV	0.540	0.867	.030	4	view →
LUAD	OS	Median	III,IV	0.222	0.627	.027	4	view →
PDAC	DFS	Median	IV	0.752	0.348	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GBP4–LSCC (OS)

Open the LSCC breakdown →