GBP3

Across TCGA pan-cancer cohorts, GBP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GBP3 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GBP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GBP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where GBP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.950	0.552	.001	42	view →
LSCC	DFS	Median	All	0.602	0.858	.003	26	view →
UCEC	OS	Median	All	1.000	0.925	.027	2	view →
HNSC	OS	Quartile	IV	1.000	0.684	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GBP3–CCRCC (DFS)

Open the CCRCC breakdown →