GBP3

Across TCGA patient cohorts, GBP3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP3-associated genes across cancer lineages are EGFR_pY1068, PCNA, and PDCD4. Each is linked with GBP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GBP3-to-partner and partner-to-GBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GBP3-low versus GBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP3→partner) and Y-score (partner→GBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.236	-3.906	.010	<.001	3	2
UCEC	PCNA →	+0.255	+2.906	.001	.001	2	3
UCEC	PDCD4 →	-0.418	-2.999	.015	.035	3	2
UCEC	PDK1_pS241 →	+0.166	+2.807	.008	.003	3	2
UCEC	Rab11 →	-0.110	-1.847	.038	.008	3	2
UCEC	Shc_pY317 →	-0.146	-2.321	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by GBP3 expression — UCEC

Explore this box plot interactively →