GBP3

Across TCGA cell cohorts, GBP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,176 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GBP3-associated GO terms across cancer lineages are Cytolysis in another organism, Regulation of cytokine-mediated signaling pathway, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with GBP3 in more than 18 cancer types. Because this analysis shows association rather than direction, both GBP3-to-partner and partner-to-GBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytolysis in another organism grouped by GBP3-low versus GBP3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP3→partner) and Y-score (partner→GBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cytolysis in another organism →	+1.917	+3.350	<.001	<.001	3	19
OVARY	Regulation of cytokine-mediated signaling pathway →	+0.098	+2.390	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.096	+2.179	<.001	.001	3	16
LUNG_SCLC	Intracellular receptor signaling pathway →	+0.071	+1.783	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Membrane biogenesis →	+0.120	+3.944	.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.186	+2.742	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,176 associations by consensus.

Cytolysis in another organism by GBP3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →