GBP2

Across TCGA cell cohorts, GBP2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GBP2-associated genes across cancer lineages are KRT77, CST11, and OR5M11. Each is linked with GBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP2-to-partner and partner-to-GBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT77 grouped by GBP2-low versus GBP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP2→partner) and Y-score (partner→GBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRT77 →	+0.065	+4.981	<.001	.008	3	2
CNS	CST11 →	+0.097	+4.981	<.001	.008	3	1
CNS	OR5M11 →	+0.049	+6.357	<.001	<.001	3	1
BLOOD_Leukemia	OBP2B →	+0.046	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KRT77 by GBP2 expression — CNS

Explore this box plot interactively →