GBP1

Across TCGA patient cohorts, GBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,086 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP1-associated genes across cancer lineages are LINC02559, CKS1BP6, and RPL22P22. Each is linked with GBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP1-to-partner and partner-to-GBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by GBP1-low versus GBP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP1→partner) and Y-score (partner→GBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.780	+6.342	<.001	.001	3	2
SKCM	CKS1BP6 →	+0.199	+2.640	.003	.005	3	2
LUSC	RPL22P22 →	+0.205	+3.743	.007	.006	3	2
UCEC	RNA5SP412 →	+0.420	+1.568	<.001	.002	3	2
COAD	RFPL1 →	+0.059	+4.278	<.001	.001	3	2
UCEC	ESS2 →	+0.277	+1.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,086 associations by consensus.

LINC02559 by GBP1 expression — CESC

Explore this box plot interactively →