GBP1

Across TCGA patient cohorts, GBP1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP1-associated genes across cancer lineages are eEF2, Cyclin-B1, and EGFR_pY1068. Each is linked with GBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GBP1-to-partner and partner-to-GBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GBP1-low versus GBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP1→partner) and Y-score (partner→GBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.270	+1.807	.015	.024	3	3
BLCA	Cyclin-B1 →	+0.724	+3.169	.002	.019	3	2
UCEC	EGFR_pY1068 →	-0.176	-1.765	.024	.013	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.369	+1.643	.019	.003	3	2
UCEC	INPP4B →	-0.286	-2.169	.004	.002	3	2
UCEC	JNK2 →	+0.215	+1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by GBP1 expression — UCEC

Explore this box plot interactively →