GBGT1

Across TCGA patient cohorts, GBGT1 mutation is significantly associated with the RNA expression of many other genes, with 1,049 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBGT1-associated genes across cancer lineages are ATP5PBP2, YWHAQP1, and CYP4F10P. Each is linked with GBGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBGT1-to-partner and partner-to-GBGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5PBP2 grouped by GBGT1-low versus GBGT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBGT1→partner) and Y-score (partner→GBGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATP5PBP2 →	+0.357	+5.017	<.001	.009	3	2
COAD	YWHAQP1 →	+0.173	+5.435	<.001	.005	3	2
COAD	CYP4F10P →	+0.253	+5.283	<.001	.006	3	2
LIHC	ZNF317P1 →	+0.154	+4.451	.001	.006	3	2
UCEC	PHF5A →	+0.452	+3.087	.003	<.001	3	2
UCEC	POLE2 →	+0.616	+3.606	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,049 associations by consensus.

ATP5PBP2 by GBGT1 expression — COAD

Explore this box plot interactively →