GBGT1

Across TCGA patient cohorts, GBGT1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBGT1-associated genes across cancer lineages are mTOR_pS2448, ATM, and EGFR_pY1068. Each is linked with GBGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBGT1-to-partner and partner-to-GBGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GBGT1-low versus GBGT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBGT1→partner) and Y-score (partner→GBGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.209	-3.446	<.001	.005	3	2
UCEC	ATM →	-0.865	-4.087	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.294	-3.000	.004	.001	3	1
UCEC	eIF4E →	+0.259	+2.598	.002	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.126	-2.105	.014	.017	3	1
UCEC	GAPDH →	+0.660	+2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by GBGT1 expression — UCEC

Explore this box plot interactively →