GBGT1

Across TCGA cell cohorts, GBGT1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBGT1-associated genes across cancer lineages are CST2, ASPN, and IL17F. Each is linked with GBGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBGT1-to-partner and partner-to-GBGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST2 grouped by GBGT1-low versus GBGT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBGT1→partner) and Y-score (partner→GBGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CST2 →	+0.355	+4.152	<.001	.009	3	1
LARGE_INTESTINE	ASPN →	+0.045	+3.378	<.001	.006	3	1
LARGE_INTESTINE	IL17F →	+0.043	+3.029	.003	.003	3	1
LARGE_INTESTINE	C6orf118 →	+0.134	+3.378	<.001	.001	3	1
LARGE_INTESTINE	MYH8 →	+0.063	+2.657	.003	.007	3	1
LARGE_INTESTINE	C9orf153 →	+0.155	+3.497	.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CST2 by GBGT1 expression — BLOOD_Leukemia

Explore this box plot interactively →